Nasreen Laiq, Muhammad Naeem Khan, Reddy C V M, Rasad P.
Prevention of postoperative nausea and vomiting by Ondansetron, in children undergoing Strabismus surgery.
Pak J Med Res Jan ;44(4):156-8.

Aims: To evaluate the antiemetic effect of controlling postoperative nausea and vomiting in children undergoing strabismus surgery. Patients and methods: It was a randomized placebo controlled, double blind study of 100 children between 5-15 years of age with American Society of Anaesthesiologists (ASA) status I and II undergoing strabismus surgery under general anaesthesia.. Patients were divided into two groups of 50 each. One group was given normal saline while the other received 75ug/kg-1 of ondansetron pre operatively. Children were monitored for the number of emetic episodes, and the need for a rescue antiemetic. Results: There was significantly high P< 0.05 frequency of vomiting 30 patients 60% in group receiving normal saline when compared to ondansetron group 15 patients 30%. The incidence of early vomiting (0-4 hour) and the need for rescue antiemetic were also very low in patients receiving ondansetron when compared with the saline group. Conclusions: Ondansetron was found to an effective drug in preventing nausea and vomiting postoperatively in children undergoing strabismus surgery.

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