Amar Lal, Nehal Masood.
Current approach to primary central nervous system Lymphoma (PCNSL).
Pak J Neurological Sci Jan ;1(3):138-44.

Central nervous system involvement with Non-Hodgkin`s Lymphoma (NHL), whether primary or secondary, is an uncommon but not rare condition. The incidence of Primary Central Nervous System Lymphoma (PCNSL) has dramatically increased during the last three decades in both immunocompromised and immunocompetent hosts. PCNSL is associated with unique diagnostic, prognostic, and therapeutic issues, and the management of this malignancy is different from that of other forms of extranodal NHL. Whole-brain radiation therapy (WBRT) alone is insufficient for durable tumor control. High-dose methotrexate (MTX) in combination with other chemotherapeutic agents followed by WBRT results in response rates approaching 100% and improved median survival times ranging between 30 and 60 months. This is a review article.

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