Re: periodontiits and pre term low birth weights
quote:
fafooden wrote:
aoa noadays this is a world wide discussion in america its a proven fact and in other countries it is not. i and my friends wanted to do a research or more like an epidemeological survey. but the problems we were facing was that we cant rule out all other problems related to pre term low birth weights coz they can be detected only by chemical means. we just have a vague idea abt this topic. if anybdy can elp us out plz give us sme gideline where to start frm and how to start. themost basic things that we need to do
I just read something about this subject and here's the summary with necessary references:
One early study found pregnant women with periodontal disease were 7- time more likely to have a premature low-birth weight (PLBW) baby than women who did not have periodontal disease. (J.Periodontol. 1996:67[suppl.10]:1103-13)
It was reported that Prostaglandin E2 was significantly higher in gingival sulcus fluid in 48 mothers of PLBW infants than in controls.(Ann. Periodontol. 1998;3:233-50)
Poor periodontal health was determined to be an independent risk factor for PLBW in a case-control study of 55 pairs of women. (Ann. Perodontol. 1998;3:206-12)
Systemic distribution of maternal periodontal infection was confirmed.(Ann. Periodontol. 2001;6:175-82)
Research linked maternal periodontal disease to an increased risk of pre-eclampsia. (Obstet.Gynecol. 2003;101:227-31)
Studies in Chile and USA, demonstrated a reduction in the incidence of PLBW among women with periodontitis who underwnt scaling and root planing in pregnancy.
A study found that periodontitis and elevated amniotic fluid cytokine levels at 15-20 weeks' gestation served as markers for preterm birth in high risk pregnancies.(J.Clin.Periodontol. 2005;32:45-52)
Periodontal disease may account for upto 18% of preterm births. (Obstet.Gynecol. 2003;101:227-31)
Posted by: chameedPosts: 173 :: 26-03-2005 :: | Reply to this Message
Re: Re: periodontiits and pre term low birth weights
quote:
fafooden wrote:
thanx 4 the rply i just want to kno tat is it possible by any means to do such a survey in pakistan and if so how? coz all these things can be confirmed by chemical analyses of amniotic fluid also a gaynacologist told us that in most cases u dnt know the cause of preterm low birth weights. if its coz of sme other infection the cytokines wud show in amniotic fluid. so quite a precise analysis seems to be involved so its now becoming even more difficult for us to design our project kindly i wud need sme suggestions and guidelines in that respect also
If I clearly understand your reply, you are trying to conduct a study in the form of a survey, without getting involved in any chemical testing. Is that your intention? If that is your intention, then the following abstract should be a guide for you:
Periodontal Therapy May Reduce the Risk of Preterm Low Birth Weight in Women With Periodontal Disease: A Randomized Controlled Trial
López NJ, Smith PC, Gutierrez J(Univ of Chile, Santiago; Hosp San José) J Periodontol, 73:911-924, 2002 4-12
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Background.—Two case-control studies and a cohort study have suggested that periodontal disease may be an independent risk factor for preterm birth and low birth weight (PLBW). The mechanism of this association may be similar to that underlying other types of maternal infections. The effects of treatment for periodontal disease on the rate of PLBW were assessed in a randomized controlled trial.
Methods.—The study included 400 pregnant women with periodontal disease who received prenatal care at a public health clinic. The women were randomly assigned to receive periodontal treatment, consisting of plaque control instruction, scaling and root planing, and chlorhexidine, either before 28 weeks' gestation or after delivery. Information on reproductive history and risk factors was determined from medical records and patient interviews. The rate of PLBW—defined as delivery before 37 weeks' gestation or birth weight less than 2500 g—was compared between treatment groups.
Results.—Three hundred fifty-one women were included in the analysis. Women receiving periodontal treatment during pregnancy had a significantly lower rate of PLBW: 1.84% compared with 10.11% in the control group, odds ratio (OR) 5.49. On multivariate analysis, periodontal disease was the strongest predictor of PLBW (OR, 4.70) (Fig 2). Other significant risk factors included previous pregnancy with PLBW (OR, 3.9
; fewer than 6 prenatal visits (OR, 3.70); and low maternal weight gain (OR 3.42).
Discussion.—These randomized trial data support the hypothesis that periodontal disease is an independent risk factor for PLBW. For pregnant women with periodontal disease, periodontal treatment during pregnancy lowers the risk of PLBW.
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Commentary
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This clinical study further corroborates the link between periodontal disease and PLBW babies. Pregnant women with periodontitis were either treated before 28 weeks of gestation or after delivery. Those receiving therapy before delivery had a significantly lower percentage of PLBW babies. While this result is only one piece of the puzzle, it does reinforce the paradigm that periodontitis has systemic effects and that it should be controlled early on in a pregnancy. However, periodontitis was only one of several risk factors that accounted for PLBW in this study.
Commentator
D. N. Dederich, DDS, MSc, PhD
[Edited by chameed on 04-03-2005 at 08:25 PM GMT]
Posted by: chameedPosts: 173 :: 03-04-2005 :: | Reply to this Message
